San Francisco 49ers

SF

San Francisco 49ers

6-6, 5-7 ATS

41

33

DET

Detroit Lions

1-10-1, 8-4 ATS

Detroit Lions

Media Consensus Picks

328 PicksMoneyline
San Francisco 49ers

SF

-428

97%

97% predicted the 49ers to win.

274 PicksSpread
Detroit Lions

DET +9.5

-108

26%

26% predicted the Lions to cover the spread.

158 PicksOver/Under

Over 46

-110

30%

30% predicted the score to be over 46.

Best Sportsbook Odds


San Francisco 49ers
SF
Team Performance
DET
Detroit Lions
Moneyline
6-6 (50%)OverallOverall1-10-1 (9%)
4-2 (67%)On RoadAt Home1-5 (17%)
5-5 (50%)As FavoriteAs Underdog1-10-1 (9%)
4-1 (80%)As Road FavoriteAs Home Underdog1-5 (17%)
Spread
5-7 (42%)OverallOverall8-4 (67%)
3-3 (50%)On RoadAt Home4-2 (67%)
4-6 (40%)As FavoriteAs Underdog8-4 (67%)
3-2 (60%)As Road FavoriteAs Home Underdog4-2 (67%)
Over-Under-Push
7-5 (58%)OverallOverall4-8 (33%)
3-3 (50%)On RoadAt Home3-3 (50%)
7-3 (70%)As FavoriteAs Underdog4-8 (33%)

What National Media Said

98% of national media analysts called the 49ers victory.

Featured National Media Analyst
Gregg Rosenthal

Gregg Rosenthal

NFL Network

SF

San Francisco 49ers

SF -7.5

49ers 27, Lions 17

“It doesn't feel right that the 49ers are a 7.5-point road favorite against a team that lost only one more game than they did a year ago. Then again, it doesn't feel right to be one of five NFL.com analysts to pick the 49ers to win it all. There is nary a position group on this 49ers roster that doesn't look loaded, with the exception of their secondary. The Lions, meanwhile, are in transition most everywhere except the offensive line. While being great up front will make Dan Campbell happy, you still need playmakers on both sides of the ball in the year 2021. ”...

September 9, 2021 via nfl.com

Featured National Media Analyst
Mike Florio

Mike Florio

ProFootballTalk

SF

San Francisco 49ers

SF -7.5

49ers 31, Lions 17

“Copy and paste the Vikings-Bengals take here. Replace 49ers for Vikings.”...

September 9, 2021 via profootballtalk.nbcsports.com

Featured National Media Analyst
Michael David Smith

Michael David Smith

ProFootballTalk

SF

Detroit Lions

DET +7.5

49ers 16, Lions 13

“The Lions won’t be quite as bad as everyone thinks, but the 49ers will be good enough to beat them in a closer game than people are expecting.”...

September 9, 2021 via profootballtalk.nbcsports.com

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San Francisco 49ers

What 49ers Insiders Said

100% of team insiders called the 49ers victory.

Featured 49ers Insider
Nick Wagoner

Nick Wagoner

ESPN NFL Nation

SF

San Francisco 49ers

SF -7.5

Over 44.5

49ers 31, Lions 23

“Much of the talk about the Niners going into this one centers on the quarterbacks, but it will be the run game -- led by back Raheem Mostert -- that will steal the show. Mostert will run for 150-plus yards and a pair of touchdowns against a Detroit defense that finished 28th in rushing yards allowed per game and gave up a league-high 27 rushing touchdowns in 2020, and then didn't make many significant moves to improve in that area in the offseason”...

September 10, 2021 via espn.com

Featured 49ers Insider
Ted Nguyen

Ted Nguyen

The Athletic

SF

September 9, 2021 via theathletic.com

Featured 49ers Insider
Ryan Adverderada

Ryan Adverderada

Full Press 49ers

SF

San Francisco 49ers

SF -8

Over 45

September 11, 2021

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Detroit Lions

What Lions Insiders Said

86% of team insiders called the 49ers victory.

Featured Lions Insider

SF

San Francisco 49ers

SF -7.5

Over 44.5

49ers 30, Lions 21

“It's truly a new era in Detroit, with Jared Goff set to become the first quarterback outside of Matthew Stafford to start a season opener since 2008. There aren't many expectations for Detroit to win more than five regular-season games, so players seem to be embracing an underdog role this season. Lions tight end T.J. Hockenson is close friends with and a former college teammate of the 49ers' George Kittle, so that'll be a matchup to watch for bragging rights at the position.”...

September 10, 2021 via espn.com

Featured Lions Insider
Ryan Mathews

Ryan Mathews

Pride of Detroit

SF

San Francisco 49ers

SF -8

Under 45

September 8, 2021

Featured Lions Insider
Andrew Kato

Andrew Kato

Pride of Detroit

SF

San Francisco 49ers

SF -8

Under 45

49ers 24, Lions 6

September 9, 2021

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Top-Ranked Expert Picks

Best performing analysts in each category this season.

Lions Overall Experts

Pete Sweeney

25-9-2 (74%)

SF

Jared Sapp

25-9-2 (74%)

SF

Aaron Leming

23-8-2 (74%)

SF
Lions Moneyline Experts

Tim Cowlishaw

11-0-1 (100%)

SF

Matt Stagner

10-0-1 (100%)

SF

Lester Wiltfong

10-1-1 (91%)

SF
Lions Spread Experts

Munaf Manji

7-0-1 (100%)

SF -8

Pete Sweeney

9-2-1 (82%)

SF -8

Perry Kostidakis

5-0-0 (100%)

DET +9
Lions Over/Under Experts

Aaron Leming

10-1-0 (91%)

Under 45.5

Daniel Belton

9-3-0 (75%)

Under 45

Garrett Williams

8-3-0 (73%)

Over 45.5
49ers Overall Experts

Christopher Dunnells

25-8-0 (76%)

SF

Jess Root

24-11-1 (69%)

SF

JSpenceTheKing

21-9-0 (70%)

SF
49ers Moneyline Experts

Jeremy Fowler

10-2-0 (83%)

SF

Zach Lowder

10-2-0 (83%)

SF

Brenden Ertle

10-2-0 (83%)

SF
49ers Spread Experts

Emmanuel Morgan

10-2-0 (83%)

SF -7

Jess Root

9-2-1 (82%)

DET +8

Pete Sweeney

9-2-1 (82%)

SF -8
49ers Over/Under Experts

Braden Holecek

9-3-0 (75%)

Over 45.5

Kenneth Cotterill

8-3-0 (73%)

Under 45.5

Michael Flores

8-3-0 (73%)

Over 45.5

Top-Ranked Staff Consensus Picks

Consensus staff picks from the best performing outlets this season.

ESPN

23-19-2 (55%)

Matchup Performance

SF (100%)Moneyline
DET -9.5 (0%)Spread
Over 46 (100%)Total
Pride of Detroit

153-100-18 (60%)

Matchup Performance

SF (92%)Moneyline
DET +9.5 (25%)Spread
Over 46 (14%)Total
Sports Illustrated

69-41-5 (63%)

Matchup Performance

SF (100%)Moneyline
DET -9.5 (0%)Spread
No O/U PicksTotal
NFL Network

177-101-11 (64%)

Matchup Performance

SF (100%)Moneyline
DET -9.5 (0%)Spread
No O/U PicksTotal